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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PTPN18
All Species:
0.91
Human Site:
S368
Identified Species:
2.22
UniProt:
Q99952
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q99952
NP_055184.2
460
50482
S368
G
A
P
A
G
A
G
S
G
T
Q
T
G
T
G
Chimpanzee
Pan troglodytes
XP_513663
807
91678
S565
D
G
T
V
F
P
S
S
L
L
P
T
S
S
T
Rhesus Macaque
Macaca mulatta
XP_001093333
456
50339
P368
G
A
P
A
G
A
G
P
G
P
E
T
G
T
G
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q61152
453
50183
P368
G
A
S
A
G
T
G
P
G
P
R
A
P
T
S
Rat
Rattus norvegicus
NP_001013129
453
50088
P368
G
A
S
G
S
T
G
P
G
T
R
A
P
N
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521024
682
72925
K539
D
T
Y
A
V
V
H
K
R
G
P
P
P
P
S
Chicken
Gallus gallus
XP_001235234
775
85980
E401
V
K
M
W
G
A
G
E
A
L
Q
K
H
R
S
Frog
Xenopus laevis
NP_001121240
511
57423
R384
P
S
S
V
P
D
P
R
P
Q
T
V
E
Y
V
Zebra Danio
Brachydanio rerio
NP_001013470
513
57261
V372
S
A
P
H
S
V
T
V
H
F
Y
D
N
A
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_796904
967
106580
I672
D
A
K
D
S
G
I
I
R
R
K
T
E
S
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
27.1
94.7
N.A.
N.A.
75.8
74.7
N.A.
36.5
27.6
42.2
39.1
N.A.
N.A.
N.A.
N.A.
22.6
Protein Similarity:
100
38.7
96.5
N.A.
N.A.
82.6
82.3
N.A.
46.9
40.6
58.7
55.3
N.A.
N.A.
N.A.
N.A.
32.4
P-Site Identity:
100
13.3
80
N.A.
N.A.
46.6
33.3
N.A.
6.6
26.6
0
13.3
N.A.
N.A.
N.A.
N.A.
13.3
P-Site Similarity:
100
20
86.6
N.A.
N.A.
53.3
40
N.A.
6.6
26.6
6.6
13.3
N.A.
N.A.
N.A.
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
60
0
40
0
30
0
0
10
0
0
20
0
10
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
30
0
0
10
0
10
0
0
0
0
0
10
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
10
0
0
10
0
20
0
0
% E
% Phe:
0
0
0
0
10
0
0
0
0
10
0
0
0
0
0
% F
% Gly:
40
10
0
10
40
10
50
0
40
10
0
0
20
0
20
% G
% His:
0
0
0
10
0
0
10
0
10
0
0
0
10
0
0
% H
% Ile:
0
0
0
0
0
0
10
10
0
0
0
0
0
0
0
% I
% Lys:
0
10
10
0
0
0
0
10
0
0
10
10
0
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
10
20
0
0
0
0
10
% L
% Met:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
10
10
10
% N
% Pro:
10
0
30
0
10
10
10
30
10
20
20
10
30
10
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
10
20
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
10
20
10
20
0
0
10
0
% R
% Ser:
10
10
30
0
30
0
10
20
0
0
0
0
10
20
40
% S
% Thr:
0
10
10
0
0
20
10
0
0
20
10
40
0
30
10
% T
% Val:
10
0
0
20
10
20
0
10
0
0
0
10
0
0
10
% V
% Trp:
0
0
0
10
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
10
0
0
0
0
0
0
0
10
0
0
10
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _